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KURŞUN ZEHİRLENMESİ
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KURŞUN ZEHİRLENMESİ
(Medicine and Hematology Glossary) :
Nedeni bulunamayan mikrositik anemilerde akla getirilmelidir. Kurşun vücuda gastro intestinal yoldan veya inhalasyonla girer. Eritroblastların mitokondrilerinde birikir ve çeşitli mitokondrial enzimleri bozar. Periferik kan yaymalarında eritrositler mikrositiktir, ancak dimorfizm yoktur. Bazofilik noktalanma (stippling) dikkati çeker. Kemik iliği incelemesinde eritropoez normoblastiktir, ringed sideroblastlar görülür. Laboratuvar incelemelerinde eritrosit protoporfirini artmıştır, idrarda delta-ALA yüksek bulunur.
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